Cytolytic and systemic toxic effects induced by the aqueous extract of the fire coral Millepora alcicornis collected in the Mexican Caribbean and detection of two types of cytolisins

Table 4 Symptoms in mice induced by intravenous administration of the aqueous extract of M. alcicornis

Dose (μg protein/g)	Symptoms	Death time
Control	Normal behavior	No death
1.5–3	Little change, affected but calm, progressive malaise, and burning	No death
6–12	Progressive agitation, respiratory difficulty, despair, malaise, later slowness, muscle paralysis of the hind leg, respiratory failure, convulsions and death; intestinal inflammation, uremia, hemolysis in the eyes and nails	Mainly within 10 h
24–48	Respiratory difficulty, hypoactivity, paralysis of the hind leg, intestinal inflammation, uremia, redness of eyes and nails, respiratory failure, convulsions, and death	Mainly within 3 h

ISSN: 1678-9199